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Research Group of Bioorganic Chemistry and Biomaterials

Research Group of Bioorganic Chemistry and Biomaterials

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Posted on 22. 11. 202017. 8. 2023 by Tomáš Strašák
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Posted on 12. 5. 202013. 4. 2023 by Tomáš Strašák
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Posted on 11. 5. 202013. 4. 2023 by Tomáš Strašák
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Posted on 11. 5. 202013. 4. 2023 by Tomáš Strašák

Latest News

We have recently published an article concerning organoruthenium glycomimetics exhibiting high selectivity and nanomolar affinity for human galectin-1.


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We have currently published an article introducing new modular type of poly(amide-carbosilane) dendrimers (PAMCAS) where we utilized organic solvent nanofiltration for their efficient preparation and purification.

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At the prestigious Transfera Technology Day 2025 competition held on 9 December 2025 in Prague, nine top Czech research projects pitched their innovations to an expert jury. Our project of selective galectin inhibitors, pitched by Dr. Vojtěch Hamala (ICPF CAS) and Kateřina Kučerová (CETAV CAS, shown bellow), was awarded second place by the jury for its outstanding potential and innovation.

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Our master's student Kateřina Hiršová won the second place in the Organic Chemistry M3 section at the traditional UCT (University of Chemistry and Technology) Student Scientific Conference with her contribution The Role of Symmetry in the Design and Synthesis of Multivalent TDG-Ruthenate Complexes for Targeted Inhibition of Galectin-1. Congratulation!

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Jindřich Karban received a grant from the Czech Health Research Council as co-investigator of a project entitled "Optimization and characterization of selective galectin-1 inhibitors based on organic ruthenium for use in cancer treatment."

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Martin Kurfiřt successfully defended his Ph. D. thesis on fluorinated N-acetylglucosamine and received a doctoral degree. Congratulations!

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Dr. Vojtěch Hamala obtained a grant from PRAK (an internal program of the Czech Academy of Sciences) to support the commercialization of his galectin inhibitors. Congratulations!

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Our student Gabriela Vlčková successfully defended her thesis, "Determination of the Lipophilicity of Fluorinated Saccharides", and received her MSc. Congratulations!

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We have recently published an article concerning functionalized carbosilane dendrimers for siRNA delivery. Three new series of cationic dendritic nanocarriers were synthesized and tested, including glycodendrimers.

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Our students, Martin Kurfiřt, Aleš Krčil and Anna Velebová participated in the international conference: Liblice 2024 – 58th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. The students presented work focused on the synthesis of new carbohydrate derivatives and the study of their interaction with human galectins. Student Anna Velebová won The Otakar Červinka Prize for the best poster. Congratulations!

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